Opposite effects of bombesin on insulin and gastrin response to food in humans.
نویسندگان
چکیده
The effect of bombesin on insulin and gastrin response to a standard labelled meal was studied in eight healthy male volunteers. The gastric emptying of solids was simultaneously evaluated. During intravenous infusion of the peptide (5 ng/kg/min) the insulin release after eating was greatly reduced whereas food stimulated gastrin release was significantly enhanced. Both effects of bombesin are likely to be connected with the marked inhibition of gastric emptying induced by the peptide.
منابع مشابه
نقش بمبزین در سیری پیش از جذب
Spontaneous cessation of eating and feeling of fullness before any digestion or absorption of food stuff begins,indicates that G.I. tract sensory nerves or hormone like secretion of upper G.I. tract can causes preabsorptive satiety. Some neurotransmitters or hormonal secretions are assumed to be responsible for this phenomenon, one of them is called bombesin, which mimics neurotransmission acti...
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Introduction: Bombesin is a 14-aminoacid peptide isolated from frog skin. The mammalian counterparts of the frog peptide are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Bombesin (BBN) is a peptide showing high affinity for the gastrin releasing peptide receptor (GRPr). Prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over...
متن کاملEffects of bombesin on gastrin and gastric acid secretion in patients with duodenal ulcer.
The effect of bombesin, a possible neurotransmitter of gastrin release, upon gastrin and gastric acid secretion was investigated in 25 patients with duodenal ulcer and in 16 normal subjects. In patients with duodenal ulcer bombesin (10 ng/kg/min) produced an increase in plasma gastrin output (median 22.4 (range 7.5-75.8) pmol/l/min) similar to that obtained in normal subjects (median 24.4 (rang...
متن کاملDecreased gastrin secretion in patients with late-onset hypogammaglobulinemia.
We undertook this study to determine whether patients with late-onset hypogammaglobulinemia, who are at very high risk for gastric cancer, have a reduced secretion of gastrin after stimulation with food or bombesin, a potent gastrin-releasing stimulus. We compared the plasma gastrin responses to bombesin and to a standard test meal in 18 patients with late-onset hypogammaglobulinemia with those...
متن کاملThe Effect of Central Injection of Ghrelin and Bombesin on Mean Plasma Thyroid Hormones Concentration
Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...
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ورودعنوان ژورنال:
- Gut
دوره 27 5 شماره
صفحات -
تاریخ انتشار 1986